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Lactose as a "Trojan horse" for quantum dot cell transport.

ABSTRACT: A series of glycan-coated quantum dots were prepared to probe the effect of glycan presentation in intracellular localization in HeLa and SV40 epithelial cells. We show that glycan density mostly impacts on cell toxicity, whereas glycan type affects the cell uptake and intracellular localization. Moreover, we show that lactose can act as a "Trojan horse" on bi-functionalized QDs to help intracellular delivery of other non-internalizable glycan moieties and largely avoid the endosomal/lysosomal degradative pathway.

SUBMITTER: Benito-Alifonso D

PROVIDER: S-EPMC4227560 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Lactose as a "Trojan horse" for quantum dot cell transport.

Benito-Alifonso David D Tremel Shirley S Hou Bo B Lockyear Harriet H Mantell Judith J Fermin David J DJ Verkade Paul P Berry Monica M Galan M Carmen MC

Angewandte Chemie (International ed. in English) 20131205 3

A series of glycan-coated quantum dots were prepared to probe the effect of glycan presentation in intracellular localization in HeLa and SV40 epithelial cells. We show that glycan density mostly impacts on cell toxicity, whereas glycan type affects the cell uptake and intracellular localization. Moreover, we show that lactose can act as a "Trojan horse" on bi-functionalized QDs to help intracellular delivery of other non-internalizable glycan moieties and largely avoid the endosomal/lysosomal d ...[more]

PMID: 24311369

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