Water mediation is essential to nucleation of ?-turn formation in peptide folding motifs.
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ABSTRACT:
SUBMITTER: Busch S
PROVIDER: S-EPMC4227566 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Publications
Water mediation is essential to nucleation of β-turn formation in peptide folding motifs.
Busch Sebastian S Bruce Chrystal D CD Redfield Christina C Lorenz Christian D CD McLain Sylvia E SE
Angewandte Chemie (International ed. in English) 20131015 49
Water-mediated bond formation: The structure of the peptide GPG-NH2 has been investigated in aqueous solution to understand the role of water in the formation of a β-turn. Using a combination of neutron diffraction enhanced by isotopic substitution, NMR spectroscopy, and computer simulations, it was found that water is an essential component to initiate folding in solution. ...[more]
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