Ontology highlight
ABSTRACT:
SUBMITTER: Lee CR
PROVIDER: S-EPMC4227774 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Lee Chang-Ro CR Kim Miri M Park Young-Ha YH Kim Yeon-Ran YR Seok Yeong-Jae YJ
Nucleic acids research 20141013 20
Similar to decapping of eukaryotic mRNAs, the RppH-catalyzed conversion of 5'-terminal triphosphate to monophosphate has recently been identified as the rate-limiting step for the degradation of a subset of mRNAs in Escherichia coli. However, the regulation of RppH pyrophosphohydrolase activity is not well understood. Because the overexpression of RppH alone does not affect the decay rate of most target mRNAs, the existence of a mechanism regulating its activity has been suggested. In this study ...[more]