Ontology highlight
ABSTRACT:
SUBMITTER: Weng KF
PROVIDER: S-EPMC4227785 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Weng Kuo-Feng KF Hung Chuan-Tien CT Hsieh Po-Ting PT Li Mei-Ling ML Chen Guang-Wu GW Kung Yu-An YA Huang Peng-Nien PN Kuo Rei-Lin RL Chen Li-Lien LL Lin Jing-Yi JY Wang Robert Yung-Liang RY Chen Shu-Jen SJ Tang Petrus P Horng Jim-Tong JT Huang Hsing-I HI Wang Jen-Ren JR Ojcius David M DM Brewer Gary G Shih Shin-Ru SR
Nucleic acids research 20141028 20
The roles of virus-derived small RNAs (vsRNAs) have been studied in plants and insects. However, the generation and function of small RNAs from cytoplasmic RNA viruses in mammalian cells remain unexplored. This study describes four vsRNAs that were detected in enterovirus 71-infected cells using next-generation sequencing and northern blots. Viral infection produced substantial levels (>10(5) copy numbers per cell) of vsRNA1, one of the four vsRNAs. We also demonstrated that Dicer is involved in ...[more]