Emerging targets in neuroinflammation-driven chronic pain.
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ABSTRACT:
SUBMITTER: Ji RR
PROVIDER: S-EPMC4228377 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
Emerging targets in neuroinflammation-driven chronic pain.
Ji Ru-Rong RR Xu Zhen-Zhong ZZ Gao Yong-Jing YJ
Nature reviews. Drug discovery 20140620 7
Current analgesics predominately modulate pain transduction and transmission in neurons and have limited success in controlling disease progression. Accumulating evidence suggests that neuroinflammation, which is characterized by infiltration of immune cells, activation of glial cells and production of inflammatory mediators in the peripheral and central nervous system, has an important role in the induction and maintenance of chronic pain. This Review focuses on emerging targets - such as chemo ...[more]
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