Rationally Designed Macrocyclic Peptides as Synergistic Agonists of LPS-Induced Inflammatory Response.
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ABSTRACT:
SUBMITTER: Gao M
PROVIDER: S-EPMC4228380 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Rationally Designed Macrocyclic Peptides as Synergistic Agonists of LPS-Induced Inflammatory Response.
Gao Meng M London Nir N Cheng Kui K Tamura Ryo R Jin Jialin J Schueler-Furman Ora O Yin Hang H
Tetrahedron 20141001 42
Toll-like receptor 4 (TLR4) plays an important role in the regulation of the innate and adaptive immune response. Both agonists and antagonists of TLR4 are of considerable interest as drug leads for various disease indications. We herein report the rational design of two myeloid differentiation factor 2 (MD2)-derived macrocyclic peptides as TLR4 modulators, using the <i>Rosetta Macromolecular Modeling</i> software. The designed cyclic peptides, but not their linear counterparts, displayed synerg ...[more]
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