Ontology highlight
ABSTRACT:
SUBMITTER: Liu K
PROVIDER: S-EPMC4228406 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Liu Ke K Lai Timothy Y Y TY Chiang Sylvia W Y SW Chan Vesta C K VC Young Alvin L AL Tam Pancy O S PO Pang Chi Pui CP Chen Li Jia LJ
Scientific reports 20141112
Neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) are leading causes of irreversible blindness in developed countries. In this study, we investigated the associations of haplotype-tagging single nucleotide polymorphisms (SNPs) in the complement component 3 (C3) gene with both neovascular AMD and PCV, and potential epistatic effects on C3. Eight tagging SNPs in C3 were genotyped in 708 unrelated study subjects: 200 neovascular AMD patients, 233 PCV pat ...[more]