Ontology highlight
ABSTRACT:
SUBMITTER: Brady N
PROVIDER: S-EPMC4228698 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Brady Nicholas N Chuntova Polly P Bade Lindsey K LK Schwertfeger Kathryn L KL
Expert review of endocrinology & metabolism 20130701 4
Fibroblast growth factor receptor (FGFR) signaling is a vital component of both embryonic and postnatal mammary gland development, which has prompted researchers to investigate both its relevance to breast cancer and its potential as a therapeutic target. Deregulated FGFR signaling during breast cancer occurs through various mechanisms, including amplification of the receptor genes, aberrant ligand expression, receptor mutations and translocations. Recent experimental outcomes involving both ani ...[more]