Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC4229023 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Zhang Xiaolan X Huang Yixian Y Zhao Wenchen W Liu Hao H Marquez Rebecca R Lu Jianqin J Zhang Peng P Zhang Yifei Y Li Jiang J Gao Xiang X Venkataramanan Raman R Xu Liang L Li Song S
Biomacromolecules 20141028 11
We have developed a dual-function drug carrier, polyethylene glycol (PEG)-derivatized farnesylthiosalicylate (FTS). Here we report that incorporation of a drug-interactive motif (Fmoc) into PEG5k-FTS2 led to further improvement in both drug loading capacity and formulation stability. Doxorubicin (DOX) formulated in PEG5k-Fmoc-FTS2 showed sustained release kinetics slower than those of DOX loaded in PEG5k-FTS2. The maximum tolerated dose of DOX- or paclitaxel (PTX)-loaded PEG5k-Fmoc-FTS2 was sign ...[more]