Gamma-range synchronization of fast-spiking interneurons can enhance detection of tactile stimuli.
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ABSTRACT:
SUBMITTER: Siegle JH
PROVIDER: S-EPMC4229565 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Gamma-range synchronization of fast-spiking interneurons can enhance detection of tactile stimuli.
Siegle Joshua H JH Pritchett Dominique L DL Moore Christopher I CI
Nature neuroscience 20140824 10
We tested the sensory impact of repeated synchronization of fast-spiking interneurons (FS), an activity pattern thought to underlie neocortical gamma oscillations. We optogenetically drove 'FS-gamma' while mice detected naturalistic vibrissal stimuli and found enhanced detection of less salient stimuli and impaired detection of more salient ones. Prior studies have predicted that the benefit of FS-gamma is generated when sensory neocortical excitation arrives in a specific temporal window 20-25 ...[more]
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