HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection.
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ABSTRACT:
SUBMITTER: Wagner TA
PROVIDER: S-EPMC4230336 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection.
Wagner Thor A TA McLaughlin Sherry S Garg Kavita K Cheung Charles Y K CY Larsen Brendan B BB Styrchak Sheila S Huang Hannah C HC Edlefsen Paul T PT Mullins James I JI Frenkel Lisa M LM
Science (New York, N.Y.) 20140710 6196
Antiretroviral treatment (ART) of HIV infection suppresses viral replication. Yet if ART is stopped, virus reemerges because of the persistence of infected cells. We evaluated the contribution of infected-cell proliferation and sites of proviral integration to HIV persistence. A total of 534 HIV integration sites (IS) and 63 adjacent HIV env sequences were derived from three study participants over 11.3 to 12.7 years of ART. Each participant had identical viral sequences integrated at the same p ...[more]
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2023-10-24 | PXD024014 | Pride
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