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Cyclic guanosine monophosphate signaling and phosphodiesterase-5 inhibitors in cardioprotection.

ABSTRACT: Cyclic guanosine monophosphate (cGMP) is an important intracellular second messenger that mediates multiple tissue and cellular responses. The cGMP pathway is a key element in the pathophysiology of the heart and its modulation by drugs such as phosphodiesterase (PDE)-5 inhibitors and guanylate cyclase activators may represent a promising therapeutic approach for acute myocardial infarction, cardiac hypertrophy, heart failure, and doxorubicin cardiotoxicity in patients. In addition, PDE-5 inhibitors may prove to be innovative therapeutic agents for enhancing the chemosensitivity of doxorubicin while providing concurrent cardiac benefit.

SUBMITTER: Kukreja RC

PROVIDER: S-EPMC4230443 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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Cyclic guanosine monophosphate signaling and phosphodiesterase-5 inhibitors in cardioprotection.

Kukreja Rakesh C RC Salloum Fadi N FN Das Anindita A

Journal of the American College of Cardiology 20120501 22

Cyclic guanosine monophosphate (cGMP) is an important intracellular second messenger that mediates multiple tissue and cellular responses. The cGMP pathway is a key element in the pathophysiology of the heart and its modulation by drugs such as phosphodiesterase (PDE)-5 inhibitors and guanylate cyclase activators may represent a promising therapeutic approach for acute myocardial infarction, cardiac hypertrophy, heart failure, and doxorubicin cardiotoxicity in patients. In addition, PDE-5 inhibi ...[more]

PMID: 22624832

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