Unknown

Dataset Information

0

World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: IV. Tissue collection, processing, and storage in endometriosis research.


ABSTRACT: OBJECTIVE:To harmonize standard operating procedures (SOPs) and standardize the recording of associated data for collection, processing, and storage of human tissues relevant to endometriosis. DESIGN:An international collaboration involving 34 clinical/academic centers and three industry collaborators from 16 countries on five continents. SETTING:In 2013, two workshops were conducted followed by global consultation, bringing together 54 leaders in endometriosis research and sample processing from around the world. PATIENT(S):None. INTERVENTION(S):Consensus SOPs were based on: 1) systematic comparison of SOPs from 24 global centers collecting tissue samples from women with and without endometriosis on a medium or large scale (publication on >100 cases); 2) literature evidence where available, or consultation with laboratory experts otherwise; and 3) several global consultation rounds. MAIN OUTCOME MEASURE(S):Standard recommended and minimum required SOPs for tissue collection, processing, and storage in endometriosis research. RESULT(S):We developed "recommended standard" and "minimum required" SOPs for the collection, processing, and storage of ectopic and eutopic endometrium, peritoneum, and myometrium, and a biospecimen data collection form necessary for interpretation of sample-derived results. CONCLUSION(S):The EPHect SOPs allow endometriosis research centers to decrease variability in tissue-based results, facilitating between-center comparisons and collaborations. The procedures are also relevant to research into other gynecologic conditions involving endometrium, myometrium, and peritoneum. The consensus SOPs are based on the best available evidence; areas with limited evidence are identified as requiring further pilot studies. The SOPs will be reviewed based on investigator feedback and through systematic triannual follow-up. Updated versions will be made available at: http://endometriosisfoundation.org/ephect.

SUBMITTER: Fassbender A 

PROVIDER: S-EPMC4230778 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: IV. Tissue collection, processing, and storage in endometriosis research.

Fassbender Amelie A   Rahmioglu Nilufer N   Vitonis Allison F AF   Viganò Paola P   Giudice Linda C LC   D'Hooghe Thomas M TM   Hummelshoj Lone L   Adamson G David GD   Becker Christian M CM   Missmer Stacey A SA   Zondervan Krina T KT  

Fertility and sterility 20140922 5


<h4>Objective</h4>To harmonize standard operating procedures (SOPs) and standardize the recording of associated data for collection, processing, and storage of human tissues relevant to endometriosis.<h4>Design</h4>An international collaboration involving 34 clinical/academic centers and three industry collaborators from 16 countries on five continents.<h4>Setting</h4>In 2013, two workshops were conducted followed by global consultation, bringing together 54 leaders in endometriosis research and  ...[more]

Similar Datasets

| S-EPMC4230690 | biostudies-literature
| S-EPMC4230639 | biostudies-literature
| S-EPMC4252538 | biostudies-literature
| S-EPMC8593963 | biostudies-literature
| S-EPMC5558683 | biostudies-other
| S-EPMC4222669 | biostudies-literature
| S-EPMC6962113 | biostudies-literature
| S-EPMC5951634 | biostudies-literature
| S-EPMC7035138 | biostudies-literature
| S-EPMC7473039 | biostudies-literature