Ontology highlight
ABSTRACT:
SUBMITTER: Ding L
PROVIDER: S-EPMC4230926 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Ding Li L Kim Minjung M Kanchi Krishna L KL Dees Nathan D ND Lu Charles C Griffith Malachi M Fenstermacher David D Sung Hyeran H Miller Christopher A CA Goetz Brian B Wendl Michael C MC Griffith Obi O Cornelius Lynn A LA Linette Gerald P GP McMichael Joshua F JF Sondak Vernon K VK Fields Ryan C RC Ley Timothy J TJ Mulé James J JJ Wilson Richard K RK Weber Jeffrey S JS
PloS one 20141113 11
To reveal the clonal architecture of melanoma and associated driver mutations, whole genome sequencing (WGS) and targeted extension sequencing were used to characterize 124 melanoma cases. Significantly mutated gene analysis using 13 WGS cases and 15 additional paired extension cases identified known melanoma genes such as BRAF, NRAS, and CDKN2A, as well as a novel gene EPHA3, previously implicated in other cancer types. Extension studies using tumors from another 96 patients discovered a large ...[more]