Ontology highlight
ABSTRACT:
SUBMITTER: He C
PROVIDER: S-EPMC4231430 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
He Congcong C Wei Yongjie Y Sun Kai K Li Binghua B Dong Xiaonan X Zou Zhongju Z Liu Yang Y Kinch Lisa N LN Khan Shaheen S Sinha Sangita S Xavier Ramnik J RJ Grishin Nick V NV Xiao Guanghua G Eskelinen Eeva-Liisa EL Scherer Philipp E PE Whistler Jennifer L JL Levine Beth B
Cell 20130815 5
The molecular mechanism of autophagy and its relationship to other lysosomal degradation pathways remain incompletely understood. Here, we identified a previously uncharacterized mammalian-specific protein, Beclin 2, which, like Beclin 1, functions in autophagy and interacts with class III PI3K complex components and Bcl-2. However, Beclin 2, but not Beclin 1, functions in an additional lysosomal degradation pathway. Beclin 2 is required for ligand-induced endolysosomal degradation of several G ...[more]