Ontology highlight
ABSTRACT:
SUBMITTER: Shalev M
PROVIDER: S-EPMC4231743 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Shalev Moran M Aviram Rona R Adamovich Yaarit Y Kraut-Cohen Judith J Shamia Tal T Ben-Dor Shifra S Golik Marina M Asher Gad G
Nucleic acids research 20140926 19
The circadian core clock circuitry relies on interlocked transcription-translation feedback loops that largely count on multiple protein interactions. The molecular mechanisms implicated in the assembly of these protein complexes are relatively unknown. Our bioinformatics analysis of short linear motifs, implicated in protein interactions, reveals an enrichment of the Pro-X-Asp-Leu-Ser (PXDLS) motif within circadian transcripts. We show that the PXDLS motif can bind to BMAL1/CLOCK and disrupt ci ...[more]