Structure of type II dehydroquinase from Pseudomonas aeruginosa.
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ABSTRACT:
SUBMITTER: Reiling S
PROVIDER: S-EPMC4231849 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
Structure of type II dehydroquinase from Pseudomonas aeruginosa.
Reiling Scott S Kelleher Alan A Matsumoto Monica M MM Robinson Gonteria G Asojo Oluwatoyin A OA
Acta crystallographica. Section F, Structural biology communications 20141025 Pt 11
Pseudomonas aeruginosa causes opportunistic infections and is resistant to most antibiotics. Ongoing efforts to generate much-needed new antibiotics include targeting enzymes that are vital for P. aeruginosa but are absent in mammals. One such enzyme, type II dehydroquinase (DHQase), catalyzes the interconversion of 3-dehydroquinate and 3-dehydroshikimate, a necessary step in the shikimate pathway. This step is vital for the proper synthesis of phenylalanine, tryptophan, tyrosine and other aroma ...[more]
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