CD4-induced activation in a soluble HIV-1 Env trimer.
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ABSTRACT:
SUBMITTER: Guttman M
PROVIDER: S-EPMC4231881 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
CD4-induced activation in a soluble HIV-1 Env trimer.
Guttman Miklos M Garcia Natalie K NK Cupo Albert A Matsui Tsutomu T Julien Jean-Philippe JP Sanders Rogier W RW Wilson Ian A IA Moore John P JP Lee Kelly K KK
Structure (London, England : 1993) 20140612 7
The HIV envelope glycoprotein (Env) trimer undergoes receptor-induced conformational changes that drive fusion of the viral and cellular membranes. Env conformational changes have been observed using low-resolution electron microscopy, but only large-scale rearrangements have been visible. Here, we use hydrogen-deuterium exchange and oxidative labeling to gain a more precise understanding of the unliganded and CD4-bound forms of soluble Env trimers (SOSIP.664), including their glycan composition ...[more]
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