Ontology highlight
ABSTRACT:
SUBMITTER: Prasad G
PROVIDER: S-EPMC4232301 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Prasad Gitanjeli G Amoroso Jon W JW Borketey Lawrence S LS Schnarr Nathan A NA
Organic & biomolecular chemistry 20120131 10
Acyl carrier proteins are critical components of fatty acid and polyketide biosynthesis. Their primary function is to shuttle intermediates between active sites via a covalently bound phosphopantetheine arm. Small molecules capable of acylating this prosthetic group will provide a simple and reversible means of introducing novel functionality onto carrier protein domains. A series of N-activated β-lactams are prepared to examine site-specific acylation of the phosphopantetheine-thiol. In general ...[more]