Poly(iohexol) nanoparticles as contrast agents for in vivo X-ray computed tomography imaging.

ABSTRACT: Biocompatible poly(iohexol) nanoparticles, prepared through cross-linking of iohexol and hexamethylene diisocyanate followed by coprecipitation of the resulting cross-linked polymer with mPEG-polylactide, were utilized as contrast agents for in vivo X-ray computed tomography (CT) imaging. Compared to conventional small-molecule contrast agents, poly(iohexol) nanoparticles exhibited substantially protracted retention within the tumor bed and a 36-fold increase in CT contrast 4 h post injection, which makes it possible to acquire CT images with improved diagnosis accuracy over a broad time frame without multiple administrations.

SUBMITTER: Yin Q 

PROVIDER: S-EPMC4232444 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature