Unknown

Dataset Information

0

Poly(iohexol) nanoparticles as contrast agents for in vivo X-ray computed tomography imaging.


ABSTRACT: Biocompatible poly(iohexol) nanoparticles, prepared through cross-linking of iohexol and hexamethylene diisocyanate followed by coprecipitation of the resulting cross-linked polymer with mPEG-polylactide, were utilized as contrast agents for in vivo X-ray computed tomography (CT) imaging. Compared to conventional small-molecule contrast agents, poly(iohexol) nanoparticles exhibited substantially protracted retention within the tumor bed and a 36-fold increase in CT contrast 4 h post injection, which makes it possible to acquire CT images with improved diagnosis accuracy over a broad time frame without multiple administrations.

SUBMITTER: Yin Q 

PROVIDER: S-EPMC4232444 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Poly(iohexol) nanoparticles as contrast agents for in vivo X-ray computed tomography imaging.

Yin Qian Q   Yap Felix Y FY   Yin Lichen L   Ma Liang L   Zhou Qin Q   Dobrucki Lawrence W LW   Fan Timothy M TM   Gaba Ron C RC   Cheng Jianjun J  

Journal of the American Chemical Society 20130904 37


Biocompatible poly(iohexol) nanoparticles, prepared through cross-linking of iohexol and hexamethylene diisocyanate followed by coprecipitation of the resulting cross-linked polymer with mPEG-polylactide, were utilized as contrast agents for in vivo X-ray computed tomography (CT) imaging. Compared to conventional small-molecule contrast agents, poly(iohexol) nanoparticles exhibited substantially protracted retention within the tumor bed and a 36-fold increase in CT contrast 4 h post injection, w  ...[more]

Similar Datasets

| S-EPMC7185737 | biostudies-literature
| S-EPMC4941627 | biostudies-literature
| S-EPMC6190607 | biostudies-literature
| S-EPMC7075218 | biostudies-literature
| S-EPMC4251562 | biostudies-literature
| S-EPMC6837195 | biostudies-literature
| S-EPMC7056796 | biostudies-literature
| S-EPMC5026601 | biostudies-literature
| S-EPMC7412782 | biostudies-literature
| S-EPMC7796949 | biostudies-literature