Ontology highlight
ABSTRACT:
SUBMITTER: Yin Q
PROVIDER: S-EPMC4232444 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Yin Qian Q Yap Felix Y FY Yin Lichen L Ma Liang L Zhou Qin Q Dobrucki Lawrence W LW Fan Timothy M TM Gaba Ron C RC Cheng Jianjun J
Journal of the American Chemical Society 20130904 37
Biocompatible poly(iohexol) nanoparticles, prepared through cross-linking of iohexol and hexamethylene diisocyanate followed by coprecipitation of the resulting cross-linked polymer with mPEG-polylactide, were utilized as contrast agents for in vivo X-ray computed tomography (CT) imaging. Compared to conventional small-molecule contrast agents, poly(iohexol) nanoparticles exhibited substantially protracted retention within the tumor bed and a 36-fold increase in CT contrast 4 h post injection, w ...[more]