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ABSTRACT: Purpose
The aim of this study was to investigate variants in UCP2 genes in type 2 diabetes mellitus (DM) and diabetic retinopathy (DR) in Chinese population.Materials and methods
We conducted a single nucleotide polymorphism-based and haplotype-based case-control study between the variants of UCP2 and DM and between the variants of UCP2 and DR in 479 Chinese patients with type 2 DM and 479 control subjects without DM. Two SNPs (rs660339 and rs659366) were selected as genetic markers.Results
The risk allele C at UCP2 rs660339 was closely associated with DM in Chinese population. There was significant difference in rs660339 between DM and controls (P = 0.0016; OR [95%CI] ?= 1.37 (1.14-1.65)). Subjects who were homozygous of the C allele were more likely to develop DM. The frequency of C allele was higher in DM (58%) than in control (51%). But this locus didn't have a definite effect on the onset of non-proliferative diabetic retinopathy (NPDR) (P = 0.44; OR [95%CI] ?= 0.80 (0.56-1.14)) and proliferative diabetic retinopathy (PDR) (P = 1.00; OR [95%CI] ?= 0.99 (0.74-1.34)) comparing to subjects with DM without retinopathy (DWR), respectively. Moreover, the UCP2 rs659366 polymorphism showed no significant difference between DM and control (P = 0.66; OR [95%CI] ?= 1.10 (0.91-1.32)). However, there was a significant difference between PDR and DWR (P = 0.016; OR [95%CI] ?= 0.66 (0.49-0.90)), but there was no difference between NPDR and DWR (P = 1.00; OR [95%CI] ?= 0.96 (0.67-1.37)). Participants who carried the G allele at rs659366 were more likely to develop PDR. For the haplotype, C-A was present more frequently in DM than in control (16% vs 7%), indicating that it was risky, and T-A was present less in DM than in control (29% vs 35%). Haplotype frequencies in DR and DWR showed no significant difference (P = 0.068).Conclusion
It was indicated that UCP2 may be implicated in the pathogenesis of type 2 DM and DR in Chinese population.
SUBMITTER: Shen Y
PROVIDER: S-EPMC4232517 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Shen Yinchen Y Wen Zujia Z Wang Ning N Zheng Zhi Z Liu Kun K Xia Xin X Gu Qing Q Shi Yongyong Y Xu Xun X
PloS one 20141114 11
<h4>Purpose</h4>The aim of this study was to investigate variants in UCP2 genes in type 2 diabetes mellitus (DM) and diabetic retinopathy (DR) in Chinese population.<h4>Materials and methods</h4>We conducted a single nucleotide polymorphism-based and haplotype-based case-control study between the variants of UCP2 and DM and between the variants of UCP2 and DR in 479 Chinese patients with type 2 DM and 479 control subjects without DM. Two SNPs (rs660339 and rs659366) were selected as genetic mark ...[more]