Structures of naturally evolved CUP1 tandem arrays in yeast indicate that these arrays are generated by unequal nonhomologous recombination.
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ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC4232551 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
Structures of naturally evolved CUP1 tandem arrays in yeast indicate that these arrays are generated by unequal nonhomologous recombination.
Zhao Ying Y Strope Pooja K PK Kozmin Stanislav G SG McCusker John H JH Dietrich Fred S FS Kokoska Robert J RJ Petes Thomas D TD
G3 (Bethesda, Md.) 20140917 11
An important issue in genome evolution is the mechanism by which tandem duplications are generated from single-copy genes. In the yeast Saccharomyces cerevisiae, most strains contain tandemly duplicated copies of CUP1, a gene that encodes a copper-binding metallothionein. By screening 101 natural isolates of S. cerevisiae, we identified five different types of CUP1-containing repeats, as well as strains that only had one copy of CUP1. A comparison of the DNA sequences of these strains indicates ...[more]
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