Ontology highlight
ABSTRACT:
SUBMITTER: Kops GJ
PROVIDER: S-EPMC423258 | biostudies-literature | 2004 Jun
REPOSITORIES: biostudies-literature
Kops Geert J P L GJ Foltz Daniel R DR Cleveland Don W DW
Proceedings of the National Academy of Sciences of the United States of America 20040524 23
A compromised mitotic checkpoint, the primary mechanism for ensuring that each new cell receives one copy of every chromosome, has been implicated as a contributor to carcinogenesis. However, a checkpoint response is shown here to be essential for cell survival, including that of chromosomally instable colorectal cancer cells. Reducing the levels of the checkpoint proteins BubR1 or Mad2 in human cancer cells or inhibiting BubR1 kinase activity provokes apoptotic cell death within six divisions e ...[more]