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Potential conservation of circadian clock proteins in the phylum Nematoda as revealed by bioinformatic searches.


ABSTRACT: Although several circadian rhythms have been described in C. elegans, its molecular clock remains elusive. In this work we employed a novel bioinformatic approach, applying probabilistic methodologies, to search for circadian clock proteins of several of the best studied circadian model organisms of different taxa (Mus musculus, Drosophila melanogaster, Neurospora crassa, Arabidopsis thaliana and Synechoccocus elongatus) in the proteomes of C. elegans and other members of the phylum Nematoda. With this approach we found that the Nematoda contain proteins most related to the core and accessory proteins of the insect and mammalian clocks, which provide new insights into the nematode clock and the evolution of the circadian system.

SUBMITTER: Romanowski A 

PROVIDER: S-EPMC4232591 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Potential conservation of circadian clock proteins in the phylum Nematoda as revealed by bioinformatic searches.

Romanowski Andrés A   Garavaglia Matías Javier MJ   Goya María Eugenia ME   Ghiringhelli Pablo Daniel PD   Golombek Diego Andrés DA  

PloS one 20141114 11


Although several circadian rhythms have been described in C. elegans, its molecular clock remains elusive. In this work we employed a novel bioinformatic approach, applying probabilistic methodologies, to search for circadian clock proteins of several of the best studied circadian model organisms of different taxa (Mus musculus, Drosophila melanogaster, Neurospora crassa, Arabidopsis thaliana and Synechoccocus elongatus) in the proteomes of C. elegans and other members of the phylum Nematoda. Wi  ...[more]

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