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Ordered, adherent layers of nanofibers enabled by supramolecular interactions.

ABSTRACT: Aligned nanofibrous substrates can be created by electrospinning, but methods for creating multilamellar structures of aligned fibers are limited. Here, apposed nanofibrous scaffolds with pendant ?-cyclodextrin (CD) were adhered together by adamantane (Ad) modified hyaluronic acid, exploiting the guest-host interactions of CD and Ad for macroscopic assembly. Stable user-defined multi-layered scaffolds were formed for cell culture or tissue engineering.

SUBMITTER: Highley CB 

PROVIDER: S-EPMC4232958 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Ordered, adherent layers of nanofibers enabled by supramolecular interactions.

Highley Christopher B CB   Rodell Christopher B CB   Kim Iris L IL   Wade Ryan J RJ   Burdick J A JA  

Journal of materials chemistry. B 20140101 46

Aligned nanofibrous substrates can be created by electrospinning, but methods for creating multilamellar structures of aligned fibers are limited. Here, apposed nanofibrous scaffolds with pendant <i>β</i>-cyclodextrin (CD) were adhered together by adamantane (Ad) modified hyaluronic acid, exploiting the guest-host interactions of CD and Ad for macroscopic assembly. Stable user-defined multi-layered scaffolds were formed for cell culture or tissue engineering. ...[more]

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