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ABSTRACT: Background
The clinical benefits of bioimpedance spectroscopy (BIS)-guided fluid management in patients on hemodialysis have been widely demonstrated. However, no previous reports have evaluated the effect of regular and serial BIS-guided fluid management on the residual renal function (RRF) in patients on peritoneal dialysis (PD). Therefore, we will evaluate the clinical efficacy of BIS-guided fluid management for preserving RRF and protecting cardiovascular events in patients on PD.Methods/design
This is a multicenter, prospective, randomized controlled trial. A total of 138 participants on PD will be enrolled and randomly assigned to receive either BIS-guided fluid management or fluid management based only on the clinical information for 1 year. The primary outcome is the change in the glomerular filtration rate (GFR) between months 0 and 12 after starting treatment. The secondary outcomes will include GFR at month 12, time to the anuric state (urine volume <100 ml/day), and fatal and nonfatal cardiovascular events during treatment.Discussion
This is the first clinical trial to investigate the effect of BIS-guided fluid management on RRF and for protecting against cardiovascular events in patients on PD.Trial registration
Clinical Trials.gov number NCT01887262, June 24, 2013.
SUBMITTER: Baek SH
PROVIDER: S-EPMC4233087 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Baek Seon Ha SH Oh Kook-Hwan KH Kim Sejoong S Kim Dong Ki DK Joo Kwon-Wook KW Oh Yun Kyu YK Han Byoung Geun BG Chang Jae Hyun JH Chung Wookyung W Kim Yon Su YS Na Ki Young KY
Trials 20141106
<h4>Background</h4>The clinical benefits of bioimpedance spectroscopy (BIS)-guided fluid management in patients on hemodialysis have been widely demonstrated. However, no previous reports have evaluated the effect of regular and serial BIS-guided fluid management on the residual renal function (RRF) in patients on peritoneal dialysis (PD). Therefore, we will evaluate the clinical efficacy of BIS-guided fluid management for preserving RRF and protecting cardiovascular events in patients on PD.<h4 ...[more]