Intrinsic frequency for a systems approach to haemodynamic waveform analysis with clinical applications.

ABSTRACT: The reductionist approach has dominated the fields of biology and medicine for nearly a century. Here, we present a systems science approach to the analysis of physiological waveforms in the context of a specific case, cardiovascular physiology. Our goal in this study is to introduce a methodology that allows for novel insight into cardiovascular physiology and to show proof of concept for a new index for the evaluation of the cardiovascular system through pressure wave analysis. This methodology uses a modified version of sparse time-frequency representation (STFR) to extract two dominant frequencies we refer to as intrinsic frequencies (IFs; ω1 and ω2). The IFs are the dominant frequencies of the instantaneous frequency of the coupled heart + aorta system before the closure of the aortic

SUBMITTER: Pahlevan NM 

PROVIDER: S-EPMC4233710 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature