Ontology highlight
ABSTRACT:
SUBMITTER: Aldeghi M
PROVIDER: S-EPMC4233953 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Aldeghi Matteo M Malhotra Shipra S Selwood David L DL Chan Ah Wing Edith AW
Chemical biology & drug design 20140401 4
Using small, flat aromatic rings as components of fragments or molecules is a common practice in fragment-based drug discovery and lead optimization. With an increasing focus on the exploration of novel biological and chemical space, and their improved synthetic accessibility, 3D fragments are attracting increasing interest. This study presents a detailed analysis of 3D and 2D ring fragments in marketed drugs. Several measures of properties were used, such as the type of ring assemblies and mole ...[more]