Ontology highlight
ABSTRACT:
SUBMITTER: Varrone JJ
PROVIDER: S-EPMC4234088 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20140703 10
Towards the development of a methicillin-resistant Staphylococcus aureus (MRSA) vaccine we evaluated a neutralizing anti-glucosaminidase (Gmd) monoclonal antibody (1C11) in a murine model of implant-associated osteomyelitis, and compared its effects on LAC USA300 MRSA versus a placebo and a Gmd-deficient isogenic strain (ΔGmd). 1C11 significantly reduced infection severity, as determined by bioluminescent imaging of bacteria, micro-CT assessment of osteolysis, and histomorphometry of abscess num ...[more]