Ontology highlight
ABSTRACT:
SUBMITTER: Asano K
PROVIDER: S-EPMC4234639 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Asano Krisana K Asano Yoshiya Y Ono Hisaya K HK Nakane Akio A
PloS one 20141117 11
Toxic shock syndrome toxin-1 (TSST-1), a superantigen produced from Staphylococcus aureus, has been reported to bind directly to unknown receptor(s) and penetrate into non-immune cells but its function is unclear. In this study, we demonstrated that recombinant TSST-1 suppresses autophagosomal accumulation in the autophagic-induced HeLa 229 cells. This suppression is shared by a superantigenic-deficient mutant of TSST-1 but not by staphylococcal enterotoxins, suggesting that autophagic suppressi ...[more]