Modeling of hypo/hyperglycemia and their impact on breast cancer progression related molecules.
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ABSTRACT:
SUBMITTER: Adham SA
PROVIDER: S-EPMC4234670 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Modeling of hypo/hyperglycemia and their impact on breast cancer progression related molecules.
Adham Sirin A I SA Al Rawahi Hasina H Habib Sumaya S Al Moundhri Mansour S MS Viloria-Petit Alicia A Coomber Brenda L BL
PloS one 20141117 11
Breast cancer (BC) arises commonly in women with metabolic dysfunction. The underlying mechanism by which glycemic load can exert its action on tumor metastasis is under investigated. In this study we showed that glycemic microenvironment alters the expression of three classes of proteins, VEGF and its receptors, cell to cell, and cell to extracellular matrix (ECM) adhesion proteins in MDA-MB-231 parental cells and its two metastatic variants to the bone and brain (MDA-MB-231BO and MDA-MB-231BR, ...[more]
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