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Epithelial CaSR deficiency alters intestinal integrity and promotes proinflammatory immune responses.


ABSTRACT: The intestinal epithelium is equipped with sensing receptor mechanisms that interact with luminal microorganisms and nutrients to regulate barrier function and gut immune responses, thereby maintaining intestinal homeostasis. Herein, we clarify the role of the extracellular calcium-sensing receptor (CaSR) using intestinal epithelium-specific Casr(-/-) mice. Epithelial CaSR deficiency diminished intestinal barrier function, altered microbiota composition, and skewed immune responses towards proinflammatory. Consequently, Casr(-/-) mice were significantly more prone to chemically induced intestinal inflammation resulting in colitis. Accordingly, CaSR represents a potential therapeutic target for autoinflammatory disorders, including inflammatory bowel diseases.

SUBMITTER: Cheng SX 

PROVIDER: S-EPMC4234694 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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Epithelial CaSR deficiency alters intestinal integrity and promotes proinflammatory immune responses.

Cheng Sam X SX   Lightfoot Yaíma L YL   Yang Tao T   Zadeh Mojgan M   Tang Lieqi L   Sahay Bikash B   Wang Gary P GP   Owen Jennifer L JL   Mohamadzadeh Mansour M  

FEBS letters 20140517 22


The intestinal epithelium is equipped with sensing receptor mechanisms that interact with luminal microorganisms and nutrients to regulate barrier function and gut immune responses, thereby maintaining intestinal homeostasis. Herein, we clarify the role of the extracellular calcium-sensing receptor (CaSR) using intestinal epithelium-specific Casr(-/-) mice. Epithelial CaSR deficiency diminished intestinal barrier function, altered microbiota composition, and skewed immune responses towards proin  ...[more]

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2018-12-04 | GSE123247 | GEO