Ontology highlight
ABSTRACT:
SUBMITTER: Cheng SX
PROVIDER: S-EPMC4234694 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
FEBS letters 20140517 22
The intestinal epithelium is equipped with sensing receptor mechanisms that interact with luminal microorganisms and nutrients to regulate barrier function and gut immune responses, thereby maintaining intestinal homeostasis. Herein, we clarify the role of the extracellular calcium-sensing receptor (CaSR) using intestinal epithelium-specific Casr(-/-) mice. Epithelial CaSR deficiency diminished intestinal barrier function, altered microbiota composition, and skewed immune responses towards proin ...[more]