Ontology highlight
ABSTRACT:
SUBMITTER: Hogg R
PROVIDER: S-EPMC4234902 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Hogg Rebecca R McGrail Joanne C JC O'Keefe Raymond T RT
Biochemical Society transactions 20100801 4
The NineTeen Complex (NTC) of proteins associates with the spliceosome during pre-mRNA splicing and is essential for both steps of intron removal. The NTC and other NTC-associated proteins are recruited to the spliceosome where they participate in regulating the formation and progression of essential spliceosome conformations required for the two steps of splicing. It is now clear that the NTC is an integral component of active spliceosomes from yeast to humans and provides essential support for ...[more]