Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants.
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ABSTRACT:
SUBMITTER: Klein F
PROVIDER: S-EPMC4235636 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants.
Klein Florian F Nogueira Lilian L Nishimura Yoshiaki Y Phad Ganesh G West Anthony P AP Halper-Stromberg Ariel A Horwitz Joshua A JA Gazumyan Anna A Liu Cassie C Eisenreich Thomas R TR Lehmann Clara C Fätkenheuer Gerd G Williams Constance C Shingai Masashi M Martin Malcolm A MA Bjorkman Pamela J PJ Seaman Michael S MS Zolla-Pazner Susan S Karlsson Hedestam Gunilla B GB Nussenzweig Michel C MC
The Journal of experimental medicine 20141110 12
Antibody-mediated immunotherapy is effective in humanized mice when combinations of broadly neutralizing antibodies (bNAbs) are used that target nonoverlapping sites on the human immunodeficiency virus type 1 (HIV-1) envelope. In contrast, single bNAbs can control simian-human immunodeficiency virus (SHIV) infection in immune-competent macaques, suggesting that the host immune response might also contribute to the control of viremia. Here, we investigate how the autologous antibody response in i ...[more]
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