Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance.
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ABSTRACT:
SUBMITTER: Shahinas D
PROVIDER: S-EPMC4235713 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
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Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance.
Shahinas Dea D Folefoc Asongna A Pillai Dylan R DR
Pathogens (Basel, Switzerland) 20130204 1
Malaria continues to exact a great human toll in tropical settings. Antimalarial resistance is rife and the parasite inexorably develops mechanisms to outwit our best drugs, including the now first-line choice, artesunate. Novel strategies to circumvent resistance are needed. Here we detail drug development focusing on heat shock protein 90 and its central role as a chaperone. A growing body of evidence supports the role for Hsp90 inhibitors as adjunctive drugs able to restore susceptibility to ...[more]
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