Global characterization of differential gene expression profiles in mouse V?1+ and V?4+ ?? T cells.
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ABSTRACT:
SUBMITTER: Dong P
PROVIDER: S-EPMC4236085 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Global characterization of differential gene expression profiles in mouse Vγ1+ and Vγ4+ γδ T cells.
Dong Peng P Zhang Siya S Cai Menghua M Kang Ning N Hu Yu Y Cui Lianxian L Zhang Jianmin J He Wei W
PloS one 20141118 11
Peripheral γδ T cells in mice are classified into two major subpopulations, Vγ1+ and Vγ4+, based on the composition of T cell receptors. However, their intrinsic differences remain unclear. In this study, we analyzed gene expression profiles of the two subsets using Illumina HiSeq 2000 Sequencer. We identified 1995 transcripts related to the activation of Vγ1+ γδ T cells, and 2158 transcripts related to the activation of Vγ4+ γδ T cells. We identified 24 transcripts differentially expressed betw ...[more]
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