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Penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.

ABSTRACT: High-level resistance to ?-lactam antibiotics in methicillin-resistant Staphylococcus aureus (MRSA) is due to expression of penicillin-binding protein 2a (PBP2a), a transpeptidase that catalyzes cell-wall crosslinking in the face of the challenge by ?-lactam antibiotics. The activity of this protein is regulated by allostery at a site 60 Å distant from the active site, where crosslinking of cell wall takes place. This review discusses the state of knowledge on this important enzyme of cell-wall biosynthesis in MRSA.

SUBMITTER: Fishovitz J 

PROVIDER: S-EPMC4236225 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.

Fishovitz Jennifer J   Hermoso Juan A JA   Chang Mayland M   Mobashery Shahriar S  

IUBMB life 20140714 8

High-level resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus (MRSA) is due to expression of penicillin-binding protein 2a (PBP2a), a transpeptidase that catalyzes cell-wall crosslinking in the face of the challenge by β-lactam antibiotics. The activity of this protein is regulated by allostery at a site 60 Å distant from the active site, where crosslinking of cell wall takes place. This review discusses the state of knowledge on this important enzyme of cell-wall  ...[more]

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