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Metabolomic profiles and childhood obesity.


ABSTRACT: To identify metabolite patterns associated with childhood obesity, to examine relations of these patterns with measures of adiposity and cardiometabolic risk, and to evaluate associations with maternal peripartum characteristics.Untargeted metabolomic profiling was used to quantify metabolites in plasma of 262 children (6-10 years). Principal components analysis was used to consolidate 345 metabolites into 18 factors and identified two that differed between obese (BMI???95‰; n?=?84) and lean children (BMI?

SUBMITTER: Perng W 

PROVIDER: S-EPMC4236243 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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<h4>Objective</h4>To identify metabolite patterns associated with childhood obesity, to examine relations of these patterns with measures of adiposity and cardiometabolic risk, and to evaluate associations with maternal peripartum characteristics.<h4>Methods</h4>Untargeted metabolomic profiling was used to quantify metabolites in plasma of 262 children (6-10 years). Principal components analysis was used to consolidate 345 metabolites into 18 factors and identified two that differed between obes  ...[more]

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