Ontology highlight
ABSTRACT:
SUBMITTER: Branzk N
PROVIDER: S-EPMC4236687 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Nature immunology 20140914 11
Neutrophils are critical for antifungal defense, but the mechanisms that clear hyphae and other pathogens that are too large to be phagocytosed remain unknown. We found that neutrophils sensed microbe size and selectively released neutrophil extracellular traps (NETs) in response to large pathogens, such as Candida albicans hyphae and extracellular aggregates of Mycobacterium bovis, but not in response to small yeast or single bacteria. NETs were fundamental in countering large pathogens in vivo ...[more]