Ontology highlight
ABSTRACT:
SUBMITTER: Casanova EL
PROVIDER: S-EPMC4237056 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Casanova Emily L EL Casanova Manuel F MF
Frontiers in cellular neuroscience 20141119
Postmortem neuropathological studies of autism consistently reveal distinctive types of malformations, including cortical dysplasias, heterotopias, and various neuronomorphometric abnormalities. In keeping with these observations, we review here that 88% of high-risk genes for autism influence neural induction and early maturation of the neuroblast. In addition, 80% of these same genes influence later stages of differentiation, including neurite and synapse development, suggesting that these gen ...[more]