Inconsistency in large pharmacogenomic studies.
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ABSTRACT:
SUBMITTER: Haibe-Kains B
PROVIDER: S-EPMC4237165 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Publications
Inconsistency in large pharmacogenomic studies.
Haibe-Kains Benjamin B El-Hachem Nehme N Birkbak Nicolai Juul NJ Jin Andrew C AC Beck Andrew H AH Aerts Hugo J W L HJ Quackenbush John J
Nature 20131127 7480
Two large-scale pharmacogenomic studies were published recently in this journal. Genomic data are well correlated between studies; however, the measured drug response data are highly discordant. Although the source of inconsistencies remains uncertain, it has potential implications for using these outcome measures to assess gene-drug associations or select potential anticancer drugs on the basis of their reported results. ...[more]
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