Autophagy gene Atg16L1 prevents lethal T cell alloreactivity mediated by dendritic cells.
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ABSTRACT:
SUBMITTER: Hubbard-Lucey VM
PROVIDER: S-EPMC4237219 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Autophagy gene Atg16L1 prevents lethal T cell alloreactivity mediated by dendritic cells.
Hubbard-Lucey Vanessa M VM Shono Yusuke Y Maurer Katie K West Mallory L ML Singer Natalie V NV Ziegler Carly G K CG Lezcano Cecilia C Motta Ana Carolina Fragoso AC Schmid Karin K Levi Samuel M SM Murphy George F GF Liu Chen C Winkler Jeffrey D JD Amaravadi Ravi K RK Rogler Gerhard G Dickinson Anne M AM Holler Ernst E van den Brink Marcel R M MR Cadwell Ken K
Immunity 20141009 4
Atg16L1 mediates the cellular degradative process of autophagy and is considered a critical regulator of inflammation based on its genetic association with inflammatory bowel disease. Here we find that Atg16L1 deficiency leads to an exacerbated graft-versus-host disease (GVHD) in a mouse model of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Atg16L1-deficient allo-HSCT recipients with GVHD displayed increased T cell proliferation due to increased dendritic cell (DC) numbers and ...[more]
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