An eIF4E-interacting peptide induces cell death in cancer cell lines.
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ABSTRACT:
SUBMITTER: Masse M
PROVIDER: S-EPMC4237268 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
An eIF4E-interacting peptide induces cell death in cancer cell lines.
Masse M M Glippa V V Saad H H Le Bloas R R Gauffeny I I Berthou C C Czjzek M M Cormier P P Cosson B B
Cell death & disease 20141030
The eukaryotic initiation factor eIF4E is essential for cap-dependent initiation of translation in eukaryotes. Abnormal regulation of eIF4E has been implicated in oncogenic transformation. We developed an eIF4E-binding peptide derived from Angel1, a partner of eIF4E that we recently identified. We show here that this peptide fused to a penetratin motif causes drastic and rapid cell death in several epithelial cancer cell lines. This necrotic cell death was characterized by a drop in ATP levels w ...[more]
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