Ontology highlight
ABSTRACT:
SUBMITTER: Bai X
PROVIDER: S-EPMC4237314 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Bai Xue X Lenhart Kaitlin C KC Bird Kim E KE Suen Alisa A AA Rojas Mauricio M Kakoki Masao M Li Feng F Smithies Oliver O Mack Christopher P CP Taylor Joan M JM
Nature communications 20130101
Although hypertension is a worldwide health issue, an incomplete understanding of its aetiology has hindered our ability to treat this complex disease. Here we identify arhgap42 (also known as GRAF3) as a Rho-specific GAP expressed specifically in smooth muscle cells (SMCs) in mice and humans. We show that GRAF3-deficient mice exhibit significant hypertension and increased pressor responses to angiotensin II and endothelin-1; these effects are prevented by treatment with the Rho-kinase inhibitor ...[more]