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ABSTRACT: Background
Cough hypersensitivity has been common among respiratory diseases.Objective
To determine associations of capsaicin cough sensitivity and clinical parameters in adults with clinically stable bronchiectasis.Methods
We recruited 135 consecutive adult bronchiectasis patients and 22 healthy subjects. History inquiry, sputum culture, spirometry, chest high-resolution computed tomography (HRCT), Leicester Cough Questionnaire scoring, Bronchiectasis Severity Index (BSI) assessment and capsaicin inhalation challenge were performed. Cough sensitivity was measured as the capsaicin concentration eliciting at least 2 (C2) and 5 coughs (C5).Results
Despite significant overlap between healthy subjects and bronchiectasis patients, both C2 and C5 were significantly lower in the latter group (all P<0.01). Lower levels of C5 were associated with a longer duration of bronchiectasis symptoms, worse HRCT score, higher 24-hour sputum volume, BSI and sputum purulence score, and sputum culture positive for P. aeruginosa. Determinants associated with increased capsaicin cough sensitivity, defined as C5 being 62.5 µmol/L or less, encompassed female gender (OR: 3.25, 95%CI: 1.35-7.83, P<0.01), HRCT total score between 7-12 (OR: 2.57, 95%CI: 1.07-6.173, P?=?0.04), BSI between 5-8 (OR: 4.05, 95%CI: 1.48-11.06, P<0.01) and 9 or greater (OR: 4.38, 95%CI: 1.48-12.93, P<0.01).Conclusion
Capsaicin cough sensitivity is heightened in a subgroup of bronchiectasis patients and associated with the disease severity. Gender and disease severity, but not sputum purulence, are independent determinants of heightened capsaicin cough sensitivity. Current testing for cough sensitivity diagnosis may be limited because of overlap with healthy subjects but might provide an objective index for assessment of cough in future clinical trials.
SUBMITTER: Guan WJ
PROVIDER: S-EPMC4237391 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Guan Wei-jie WJ Gao Yong-hua YH Xu Gang G Lin Zhi-ya ZY Tang Yan Y Li Hui-min HM Lin Zhi-min ZM Zheng Jin-ping JP Chen Rong-chang RC Zhong Nan-shan NS
PloS one 20141119 11
<h4>Background</h4>Cough hypersensitivity has been common among respiratory diseases.<h4>Objective</h4>To determine associations of capsaicin cough sensitivity and clinical parameters in adults with clinically stable bronchiectasis.<h4>Methods</h4>We recruited 135 consecutive adult bronchiectasis patients and 22 healthy subjects. History inquiry, sputum culture, spirometry, chest high-resolution computed tomography (HRCT), Leicester Cough Questionnaire scoring, Bronchiectasis Severity Index (BSI ...[more]