Ontology highlight
ABSTRACT:
SUBMITTER: Polzer B
PROVIDER: S-EPMC4237466 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Polzer Bernhard B Medoro Gianni G Pasch Sophie S Fontana Francesca F Zorzino Laura L Pestka Aurelia A Andergassen Ulrich U Meier-Stiegen Franziska F Czyz Zbigniew T ZT Alberter Barbara B Treitschke Steffi S Schamberger Thomas T Sergio Maximilian M Bregola Giulia G Doffini Anna A Gianni Stefano S Calanca Alex A Signorini Giulio G Bolognesi Chiara C Hartmann Arndt A Fasching Peter A PA Sandri Maria T MT Rack Brigitte B Fehm Tanja T Giorgini Giuseppe G Manaresi Nicolò N Klein Christoph A CA
EMBO molecular medicine 20141101 11
Several hundred clinical trials currently explore the role of circulating tumor cell (CTC) analysis for therapy decisions, but assays are lacking for comprehensive molecular characterization of CTCs with diagnostic precision. We therefore combined a workflow for enrichment and isolation of pure CTCs with a non-random whole genome amplification method for single cells and applied it to 510 single CTCs and 189 leukocytes of 66 CTC-positive breast cancer patients. We defined a genome integrity inde ...[more]