Computational approaches for modeling GPCR dimerization.
Ontology highlight
ABSTRACT:
SUBMITTER: Meng XY
PROVIDER: S-EPMC4237661 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Computational approaches for modeling GPCR dimerization.
Meng Xuan-Yu XY Mezei Mihaly M Cui Meng M
Current pharmaceutical biotechnology 20140101 10
Growing experimental evidences suggest that dimerization and oligomerization are important for G Protein- Coupled Receptors (GPCRs) function. The detailed structural information of dimeric/oligomeric GPCRs would be very important to understand their function. Although it is encouraging that recently several experimental GPCR structures in oligomeric forms have appeared, experimental determination of GPCR structures in oligomeric forms is still a big challenge, especially in mimicking the membran ...[more]
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