Ontology highlight
ABSTRACT:
SUBMITTER: Campbell SL
PROVIDER: S-EPMC4237714 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Campbell Susan L SL Robel Stefanie S Cuddapah Vishnu A VA Robert Stephanie S Buckingham Susan C SC Kahle Kristopher T KT Sontheimer Harald H
Glia 20140726 1
Seizures frequently accompany gliomas and often escalate to peritumoral epilepsy. Previous work revealed the importance of tumor-derived excitatory glutamate (Glu) release mediated by the cystine-glutamate transporter (SXC) in epileptogenesis. We now show a novel contribution of GABAergic disinhibition to disease pathophysiology. In a validated mouse glioma model, we found that peritumoral parvalbumin-positive GABAergic inhibitory interneurons are significantly reduced, corresponding with defici ...[more]