Ontology highlight
ABSTRACT:
SUBMITTER: Wu HJ
PROVIDER: S-EPMC4238106 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Wu Hsing-Ju HJ Seib Kate L KL Srikhanta Yogitha N YN Edwards Jennifer J Kidd Stephen P SP Maguire Tina L TL Hamilton Amanda A Pan Kuan-Tin KT Hsiao He-Hsuan HH Yao Chen-Wen CW Grimmond Sean M SM Apicella Michael A MA McEwan Alastair G AG Wang Andrew H-J AH Jennings Michael P MP
Journal of proteomics 20091211 5
Neisseria gonorrhoeae has evolved a complex and novel network of oxidative stress responses, including defence mechanisms that are dependent on manganese (Mn). We performed systematic analyses at the transcriptomic and proteomic (1D SDS-PAGE and Isotope-Coded Affinity Tag [ICAT]) levels to investigate the global expression changes that take place in a high Mn environment, which results in a Mn-dependent oxidative stress resistance phenotype. These studies revealed that there were proteins regula ...[more]