Leptin regulates the reward value of nutrient.
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ABSTRACT:
SUBMITTER: Domingos AI
PROVIDER: S-EPMC4238286 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Publications
Leptin regulates the reward value of nutrient.
Domingos Ana I AI Vaynshteyn Jake J Voss Henning U HU Ren Xueying X Gradinaru Viviana V Zang Feng F Deisseroth Karl K de Araujo Ivan E IE Friedman Jeffrey J
Nature neuroscience 20111113 12
We developed an assay for quantifying the reward value of nutrient and used it to analyze the effects of metabolic state and leptin. In this assay, mice chose between two sippers, one of which dispensed water and was coupled to optogenetic activation of dopaminergic (DA) neurons and the other of which dispensed natural or artificial sweeteners. This assay measured the reward value of sweeteners relative to lick-induced optogenetic activation of DA neurons. Mice preferred optogenetic stimulation ...[more]
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2019-07-02 | GSE130701 | GEO